Acid-PEG4-mono-methyl ester

• CAT Number: I016721
• CAS Number: 2028284-75-3
• Molecular Formula: C13H24O8
• Molecular Weight: 308.32
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-(3-methoxy-3-oxopropoxy)ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C13H24O8/c1-17-13(16)3-5-19-7-9-21-11-10-20-8-6-18-4-2-12(14)15/h2-11H2,1H3,(H,14,15)
• InChIKey: MOGNNSWXCSXEEM-UHFFFAOYSA-N
• SMILES: COC(=O)CCOCCOCCOCCOCCC(=O)O

Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Kanazaki K, et al. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23.
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