Acid-PEG5-mono-methyl ester

• CAT Number: I015964
• CAS Number: 1309460-30-7
• Molecular Formula: C15H28O9
• Molecular Weight: 352.38
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-(3-methoxy-3-oxopropoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C15H28O9/c1-19-15(18)3-5-21-7-9-23-11-13-24-12-10-22-8-6-20-4-2-14(16)17/h2-13H2,1H3,(H,16,17)
• InChIKey: LSGMOHWEFFVQEO-UHFFFAOYSA-N
• SMILES: COC(=O)CCOCCOCCOCCOCCOCCC(=O)O

Acid-PEG5-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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