Acitretin sodium

• CAT Number: I005510
• CAS Number: 925701-88-8
• Molecular Formula: C21H25NaO3
• Molecular Weight: 348.41
• Purity: ≥95%
• Synonyms: Ro 10-1670
• Target: RAR/RXR
• Solubility: DMSO 20 mg/mL; Water <1 mg/mL
• Storage: Store at -20C
• IUPAC Name: sodium;(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
• InChI: InChI=1S/C21H26O3.Na/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4;/h7-13H,1-6H3,(H,22,23);/q;+1/p-1/b9-7+,11-10+,14-8+,15-12+
• InChIKey: ZLNPVBQOHHEBBD-WMOHYEITSA-M
• SMILES: CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)[O-])/C)/C)C)C)OC.[Na+]

Acitretin Sodium（Cat No.:I005510）is a sodium salt form of acitretin, a second-generation retinoid primarily used in the treatment of severe psoriasis and other keratinization disorders. By regulating the growth and differentiation of skin cells, acitretin sodium helps to normalize hyperkeratinization and reduce the formation of scaly plaques. Its mechanism involves binding to nuclear retinoic acid receptors, influencing gene expression to promote healthier skin regeneration. Due to its potent effects, acitretin sodium is often used in cases resistant to other therapies, but it requires careful monitoring for potential side effects.

Reference

[1]. Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6(10):1725-34. 


[2]. Seng r B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20(6):689-92.