Acorafloxacin

For research use only. Not for therapeutic Use.

  • CAT Number: I000485
  • CAS Number: 878592-87-1
  • Molecular Formula: C21H23F2N3O4
  • Molecular Weight: 419.42
  • Purity: ≥95%
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Acorafloxacin(Cat No.:I000485)is a fluoroquinolone antibiotic with broad-spectrum activity, effective against various Gram-positive and Gram-negative bacteria. It operates by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication and transcription, leading to cell death. Acorafloxacin is explored primarily for its potential in treating respiratory, urinary tract, and skin infections. Its potency and pharmacokinetic profile make it a candidate in research for combating resistant bacterial strains. Acorafloxacin’s development highlights ongoing efforts to enhance fluoroquinolone efficacy while managing resistance and safety concerns.


Catalog Number I000485
CAS Number 878592-87-1
Synonyms

JNJ-32729463; JNJ 32729463; JNJ32729463; JNJ-32729463-AAA; JNJ32729463-AAA; JNJ 32729463-AAA; JNJ-Q2; Acorafloxacin;(E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Molecular Formula C21H23F2N3O4
Purity ≥95%
Target Bacterial; Antibiotic
Solubility Soluble in DMSO, not in water
Storage Store at -20°C
IUPAC Name 7-[(3E)-3-(2-amino-1-fluoroethylidene)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
InChI InChI=1S/C21H23F2N3O4/c1-30-20-17-13(19(27)14(21(28)29)10-26(17)12-4-5-12)7-15(22)18(20)25-6-2-3-11(9-25)16(23)8-24/h7,10,12H,2-6,8-9,24H2,1H3,(H,28,29)/b16-11+
InChIKey VMKVDAAFMQKZJS-LFIBNONCSA-N
SMILES COC1=C2C(=CC(=C1N3CCC/C(=C(/CN)\F)/C3)F)C(=O)C(=CN2C4CC4)C(=O)O

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