For research use only. Not for therapeutic Use.
Acorafloxacin(Cat No.:I000485)is a fluoroquinolone antibiotic with broad-spectrum activity, effective against various Gram-positive and Gram-negative bacteria. It operates by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication and transcription, leading to cell death. Acorafloxacin is explored primarily for its potential in treating respiratory, urinary tract, and skin infections. Its potency and pharmacokinetic profile make it a candidate in research for combating resistant bacterial strains. Acorafloxacin’s development highlights ongoing efforts to enhance fluoroquinolone efficacy while managing resistance and safety concerns.
Catalog Number | I000485 |
CAS Number | 878592-87-1 |
Synonyms | JNJ-32729463; JNJ 32729463; JNJ32729463; JNJ-32729463-AAA; JNJ32729463-AAA; JNJ 32729463-AAA; JNJ-Q2; Acorafloxacin;(E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
Molecular Formula | C21H23F2N3O4 |
Purity | ≥95% |
Target | Bacterial; Antibiotic |
Solubility | Soluble in DMSO, not in water |
Storage | Store at -20°C |
IUPAC Name | 7-[(3E)-3-(2-amino-1-fluoroethylidene)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid |
InChI | InChI=1S/C21H23F2N3O4/c1-30-20-17-13(19(27)14(21(28)29)10-26(17)12-4-5-12)7-15(22)18(20)25-6-2-3-11(9-25)16(23)8-24/h7,10,12H,2-6,8-9,24H2,1H3,(H,28,29)/b16-11+ |
InChIKey | VMKVDAAFMQKZJS-LFIBNONCSA-N |
SMILES | COC1=C2C(=CC(=C1N3CCC/C(=C(/CN)\F)/C3)F)C(=O)C(=CN2C4CC4)C(=O)O |