ACP-105

• CAT Number: R036611
• CAS Number: 899821-23-9
• Molecular Formula: C16H19ClN2O
• Molecular Weight: 290.79
• Purity: ≥95%
• Synonyms: ACP 105;ACP105;2-Chloro-4-[(3-endo)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]oct-8-yl]-3-methylbenzonitrile
• Target: Androgen Receptor
• Storage: RT
• IUPAC Name: 2-chloro-4-[(1R,5R)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl]-3-methylbenzonitrile
• InChI: InChI=1S/C16H19ClN2O/c1-10-14(6-3-11(9-18)15(10)17)19-12-4-5-13(19)8-16(2,20)7-12/h3,6,12-13,20H,4-5,7-8H2,1-2H3/t12-,13-/m1/s1
• InChIKey: OUEODVPKPRQETQ-CHWSQXEVSA-N
• SMILES: CC1=C(C=CC(=C1Cl)C#N)N2C3CCC2CC(C3)(C)O

ACP-105(CAS 899821-23-9) is a non-steroidal selective androgen receptor modulator used in the treatment of Alzheimer’s.

Reference

1: Thevis M, Thomas A, Piper T, Krug O, Delahaut P, Schänzer W. Liquid chromatography-high resolution/ high accuracy (tandem) mass spectrometry-based identification of in vivo generated metabolites of the selective androgen receptor modulator ACP-105 for doping control purposes. Eur J Mass Spectrom (Chichester). 2014;20(1):73-83. PubMed PMID: 24881457.
2: Thevis M, Piper T, Beuck S, Geyer H, Schänzer W. Expanding sports drug testing assays: mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP-105. Rapid Commun Mass Spectrom. 2013 Jun 15;27(11):1173-82. doi: 10.1002/rcm.6558. PubMed PMID: 23650030.
3: Dayger C, Villasana L, Pfankuch T, Davis M, Raber J. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. Brain Res. 2011 Mar 24;1381:134-40. doi: 10.1016/j.brainres.2010.12.088. Epub 2011 Jan 8. PubMed PMID: 21219889; PubMed Central PMCID: PMC3048897.