Acridine red

• CAT Number: I014024
• CAS Number: 2465-29-4
• Molecular Formula: C15H151lN2O
• Molecular Weight: 274.75
• Purity: ≥95%
• Synonyms: Acridine Red; 3B Acridine red hydrochloride; C.I. 45000; CI 45000;3H-Xanthen-6-amine, N-methyl-3-(methylimino)-, monohydrochloride (8CI)(9CI)
• Solubility: Soluble in DMSO
• IUPAC Name: methyl-[6-(methylamino)xanthen-3-ylidene]azanium;chloride
• InChI: InChI=1S/C15H14N2O.ClH/c1-16-12-5-3-10-7-11-4-6-13(17-2)9-15(11)18-14(10)8-12;/h3-9,16H,1-2H3;1H
• InChIKey: IVHDZUFNZLETBM-UHFFFAOYSA-N
• SMILES: CNC1=CC2=C(C=C1)C=C3C=CC(=[NH+]C)C=C3O2.[Cl-]

Acridine red（Cat No.:I014024）is a fluorescent dye commonly used in biological and microbiological research for staining nucleic acids, particularly DNA and RNA. It intercalates between the base pairs of nucleic acids, producing fluorescence under ultraviolet (UV) light. Acridine red is often utilized in cytology to distinguish between acidic and basic cellular components. When used in microscopy, it can provide contrast for identifying cellular structures, such as the nucleus. Additionally, it can be used in the assessment of apoptosis, as it exhibits differential staining of viable and non-viable cells.

Reference

1: Brown NJ, Reed MW. Leucocyte interactions with the mouse cremaster muscle microcirculation in vivo in response to tumour-conditioned medium. Br J Cancer. 1997;75(7):993-9. PubMed PMID: 9083334; PubMed Central PMCID: PMC2222733.2: Kawagoishi N, Nojiri C, Senshu K, Kido T, Nagai H, Kanamori T, Sakai K, Koyanagi H, Akutsu T. In vitro evaluation of platelet/biomaterial interactions in an epifluorescent video microscopy combined with a parallel plate flow cell. Artif Organs. 1994 Aug;18(8):588-95. PubMed PMID: 7993194.3: van Leengoed E, Versteeg J, van der Veen N, van den Berg-Blok A, Marijnissen H, Star W. Tissue-localizing properties of some photosensitizers studied by in vivo fluorescence imaging. J Photochem Photobiol B. 1990 Jun;6(1-2):111-9. PubMed PMID: 2121928.4: Piette J, Calberg-Bacq CM, Van de Vorst A. Photodynamic activity of dyes with different DNA binding properties II. T4 phage inactivation. Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Sep;34(3):223-32. PubMed PMID: 309450.5: UMEDA M. Experimental study of xanthene dye (acridine red) as carcinogenic agent, with additional study on carcinogenic action of xanthene. Gan. 1956 Dec;47(3-4):596-7. PubMed PMID: 13415147.6: UMEDA M. Sarcoma production by injections of acridine red; a supplement to experimental study of xanthene dyes as carcinogenic agents. Gan. 1956 Jul;47(2):153-8. PubMed PMID: 13344802.