Acridone-4-carboxylic acid

• CAT Number: R071797
• CAS Number: 24782-64-7
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• Purity: ≥95%
• Synonyms: 9-oxo-10H-acridine-4-carboxylic acid
• InChI: InChI=1S/C14H9NO3/c16-13-8-4-1-2-7-11(8)15-12-9(13)5-3-6-10(12)14(17)18/h1-7H,(H,15,16)(H,17,18)
• InChIKey: BATAOFZEDHPRTM-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)C3=C(N2)C(=CC=C3)C(=O)O

Acridone-4-carboxylic acid (ACA) (Compound 2c) is a heme-interacting acridone derivatives that prevents free heme-mediated protein oxidation and degradation. Acridone-4-carboxylic acid inhibits protein carbonyl formation with an IC50 of 43 μM[1].

Reference

[1]. Pal C, et al. Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3563-7.
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