For research use only. Not for therapeutic Use.
Acriflavine (Cat.No:I020641) is a synthetic compound used as an antiseptic and dye for biological specimens. It has been used to treat a range of infections, including skin and wound infections, and is also used in research as a fluorescent probe for DNA and RNA. Acriflavine has been shown to have antimicrobial and antiviral properties.
| Catalog Number | I020641 |
| CAS Number | 8048-52-0 |
| Molecular Formula | C27H25ClN6 |
| Purity | ≥95% |
| Target | HIF/HIF Prolyl-Hydroxylase |
| IUPAC Name | acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride |
| InChI | InChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H |
| InChIKey | PEJLNXHANOHNSU-UHFFFAOYSA-N |
| SMILES | C[N+]1=C2C=C(C=CC2=CC3=C1C=C(C=C3)N)N.C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.[Cl-] |
| Reference | [1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.<br>[2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588.<br>[3]. Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45. |
