For research use only. Not for therapeutic Use.
AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner[1][2].
AD 01 (≥0.003 mg/kg/day, ip) exhibits significant anti-tumor activity in DU145 tumors[1].
| Catalog Number | I015117 |
| CAS Number | 959961-23-0 |
| Molecular Formula | C115H187N33O42 |
| Purity | ≥95% |
| Reference | [1]. Andrea Valentine, et al. FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin Cancer Res. 2011 Mar 1;17(5):1044-56. [2]. Anita Yakkundi, et al. The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS One. 2013;8(2):e55075. |
