For research use only. Not for therapeutic Use.
ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].
| Catalog Number | I042016 |
| CAS Number | 294648-66-1 |
| Synonyms | 5-ethyl-5′-phenylspiro[1H-indole-3,2′-3H-1,3,4-thiadiazole]-2-one |
| Molecular Formula | C17H15N3OS |
| Purity | ≥95% |
| InChI | InChI=1S/C17H15N3OS/c1-2-11-8-9-14-13(10-11)17(16(21)18-14)20-19-15(22-17)12-6-4-3-5-7-12/h3-10,20H,2H2,1H3,(H,18,21) |
| InChIKey | ICJWVAKZQXYHBB-UHFFFAOYSA-N |
| SMILES | CCC1=CC2=C(C=C1)NC(=O)C23NN=C(S3)C4=CC=CC=C4 |
| Reference | [1]. Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74. [2]. Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633. |
