Adapalene

• CAT Number: A000191
• CAS Number: 106685-40-9
• Molecular Formula: C28H28O3
• Molecular Weight: 412.50
• Purity: ≥95%
• Synonyms: 106685-40-9; Differin; Adapalenum; Adapaleno; 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid
• Target: RARβ and RARγ agonist
• Storage: -20°C
• IUPAC Name: 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
• InChI: InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
• InChIKey: LZCDAPDGXCYOEH-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5

Adapalene（Cat No.:A000191）is a third-generation topical retinoid commonly used to treat acne. By modulating cellular differentiation, keratinization, and inflammatory processes, adapalene prevents clogged pores and reduces acne lesions. It binds selectively to retinoic acid receptors, promoting skin cell turnover and reducing inflammation, making it effective against both comedonal and inflammatory acne. Known for its stability and reduced skin irritation compared to other retinoids, adapalene is favored in dermatology. Its anti-inflammatory and comedolytic effects also make it valuable for research into other skin conditions, such as photoaging and hyperpigmentation.

Reference

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