Adapalene sodium salt

• CAT Number: I005429
• CAS Number: 911110-93-5
• Molecular Formula: C28H27NaO3
• Molecular Weight: 434.50
• Purity: ≥95%
• Synonyms: CD 271; Differin
• Target: Retinoic acid receptor
• Solubility: DMSO 8 mg/mL; Water <1 mg/mL
• Storage: Desiccate at -20C
• IUPAC Name: sodium;6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylate
• InChI: InChI=1S/C28H28O3.Na/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28;/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30);/q;+1/p-1
• InChIKey: ZETRSPVFAAAMSF-UHFFFAOYSA-M
• SMILES: COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)[O-])C45CC6CC(C4)CC(C6)C5.[Na+]

Adapalene sodium salt（Cat No.:I005429）is a stable, water-soluble form of adapalene, a third-generation retinoid primarily used in dermatology for treating acne and other skin disorders. As a modulator of cellular differentiation and keratinization, it reduces inflammation and comedone formation by binding to retinoic acid receptors (RARs) in the skin, promoting cell turnover. Its anti-inflammatory and comedolytic effects make Adapalene sodium salt valuable in research for acne treatments and skin health. This compound offers improved solubility, facilitating studies and formulations where aqueous stability is beneficial for topical applications.

Reference

[1]. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7. 


[2]. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.