For research use only. Not for therapeutic Use.
Adarotene（Cat No.:I003744）, also known as ST1926, is not only an effective apoptosis inducer but also surprisingly capable of producing DNA damage. This compound demonstrates potent antiproliferative activity against a wide range of human tumor cells. Its ability to induce apoptosis, coupled with the generation of DNA damage, makes it a promising candidate for anticancer therapies. Adarotene’s impact on tumor cell growth and viability highlights its potential as a targeted therapeutic agent for various types of cancer.
| Catalog Number | I003744 |
| CAS Number | 496868-77-0 |
| Synonyms | (E)-3-[4-[3-(1-adamantyl)-4-hydroxyphenyl]phenyl]prop-2-enoic acid |
| Molecular Formula | C25H26O3 |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 0.12 uM (LNCaP cell) |
| IUPAC Name | (E)-3-[4-[3-(1-adamantyl)-4-hydroxyphenyl]phenyl]prop-2-enoic acid |
| InChI | InChI=1S/C25H26O3/c26-23-7-6-21(20-4-1-16(2-5-20)3-8-24(27)28)12-22(23)25-13-17-9-18(14-25)11-19(10-17)15-25/h1-8,12,17-19,26H,9-11,13-15H2,(H,27,28)/b8-3+ |
| InChIKey | QAWBIEIZDDIEMW-FPYGCLRLSA-N |
| SMILES | C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC=C(C=C5)C=CC(=O)O)O |
| Reference | </br>1:Stimulation of Erythrocyte Cell Membrane Scrambling by Adarotene. Mischitelli M, Jemaàa M, Fezai M, Almasry M, Lang F, Faggio C.Cell Physiol Biochem. 2017;41(2):519-529. doi: 10.1159/000456942. Epub 2017 Jan 30. PMID: 28214860 Free Article</br>2:New retinoid derivatives as back-ups of Adarotene. Giannini G, Brunetti T, Battistuzzi G, Alloatti D, Quattrociocchi G, Cima MG, Merlini L, Dallavalle S, Cincinelli R, Nannei R, Vesci L, Bucci F, Foderà R, Guglielmi MB, Pisano C, Cabri W.Bioorg Med Chem. 2012 Apr 1;20(7):2405-15. doi: 10.1016/j.bmc.2012.01.042. Epub 2012 Feb 6. PMID: 22365912 |
