Adefovir Dipivoxil

• CAT Number: A000851
• CAS Number: 142340-99-6
• Molecular Formula: C20H32N5O8P
• Molecular Weight: 501.47
• Purity: ≥95%
• Synonyms: 142340-99-6; Hepsera; Preveon; Adefovir pivoxil; Bis-POM PMEA
• Target: CMV
• Solubility: >18.7mg/mL in DMSO
• Storage: -20°C
• InChI: InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
• InChIKey: WOZSCQDILHKSGG-UHFFFAOYSA-N
• SMILES: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C

Adefovir Dipivoxil（Cat No.:A000851）is an antiviral prodrug primarily used to treat chronic hepatitis B virus (HBV) infection. Once ingested, it is converted into its active form, adefovir, which inhibits viral DNA polymerase, preventing HBV replication and reducing viral load in the liver. This action helps decrease liver damage and the risk of developing cirrhosis or liver cancer. Known for its efficacy against lamivudine-resistant HBV strains, Adefovir Dipivoxil is valued in antiviral therapy regimens. With a favorable safety profile, it provides an essential option in long-term hepatitis B management.

Reference

1: Shi H, Han Z, Liu J, Xue J, Zhang S, Zhu Z, Xia J, Huang M. Comparing Efficacy
of Lamivudine, Adefovir Dipivoxil, Telbivudine, and Entecavir in Treating
Nucleoside Analogues Naïve for HBeAg-Negative Hepatitis B with Medium Hepatitis B
Virus (HBV) DNA Levels. Med Sci Monit. 2017 Nov 2;23:5230-5236. PubMed PMID:
29095799; PubMed Central PMCID: PMC5680675.

2: Sun Y, Wu K, Shen F, Qiu L, Chen B, Yu L, Chang S. Effects of the combined
administration of entecavir and adefovir dipivoxil to improve hepatic fibrosis in
hepatitis B patients with interferon resistance. Minerva Med. 2017
Dec;108(6):507-512. doi: 10.23736/S0026-4806.17.05222-3. Epub 2017 Sep 8. PubMed
PMID: 28889724.

3: Abdelbary GA, Amin MM, Zakaria MY, El Awdan SA. Adefovir dipivoxil loaded
proliposomal powders with improved hepatoprotective activity: formulation,
optimization, pharmacokinetic, and biodistribution studies. J Liposome Res. 2017
Aug 24:1-16. doi: 10.1080/08982104.2017.1363228. [Epub ahead of print] PubMed
PMID: 28768431.

4: Seo JW, Hwang KM, Lee SH, Kim DW, Park ES. Preparation and characterization of
adefovir dipivoxil-stearic acid cocrystal with enhanced physicochemical
properties. Pharm Dev Technol. 2017 Jun 11:1-10. doi:
10.1080/10837450.2017.1334664. [Epub ahead of print] PubMed PMID: 28535125.

5: Darsazan B, Shafaati A, Mortazavi SA, Zarghi A. A Simple and Specific
Stability- Indicating RP-HPLC Method for Routine Assay of Adefovir Dipivoxil in
Bulk and Tablet Dosage Form. Iran J Pharm Res. 2017 Winter;16(1):132-139. PubMed
PMID: 28496468; PubMed Central PMCID: PMC5423240.

6: Lin Y, Pan F, Wang Y, Chen Z, Lin C, Yao L, Zhang X, Zhou R, Pan C. Adefovir
dipivoxil-induced Fanconi syndrome and its predictive factors: A study of 28
cases. Oncol Lett. 2017 Jan;13(1):307-314. doi: 10.3892/ol.2016.5393. Epub 2016
Nov 17. PubMed PMID: 28123560; PubMed Central PMCID: PMC5244885.

7: Luo Q, Deng Y, Cheng F, Kang J, Zhong S, Zhang D, Zeng W. Relationship between
nephrotoxicity and long-term adefovir dipivoxil therapy for chronic hepatitis B:
A meta-analysis. Medicine (Baltimore). 2016 Dec;95(50):e5578. PubMed PMID:
27977591; PubMed Central PMCID: PMC5268037.

8: Zhong JH, Ke Y, Zhu SL, Wang L, Luo CP, Gong WF, You XM, Ma L, Xiang BD, Li
LQ. Adefovir dipivoxil is less expensive than lamivudine and associated with
similar prognosis in patients with hepatitis B virus-related hepatocellular
carcinoma after radical resection. Onco Targets Ther. 2016 Nov 10;9:6897-6907.
eCollection 2016. PubMed PMID: 27877054; PubMed Central PMCID: PMC5108611.

9: Wei Z, He JW, Fu WZ, Zhang ZL. Osteomalacia induced by long-term low-dose
adefovir dipivoxil: Clinical characteristics and genetic predictors. Bone. 2016
Dec;93:97-103. doi: 10.1016/j.bone.2016.09.017. Epub 2016 Sep 21. PubMed PMID:
27664568.

10: Tian L, Fu Q, Huang F. Effect of adefovir dipivoxil on T cell immune function
in the treatment of chronic hepatitis B and hepatocirrhosis. Exp Ther Med. 2016
Oct;12(4):2511-2514. Epub 2016 Aug 29. PubMed PMID: 27698751; PubMed Central
PMCID: PMC5038382.