Adefovir

• CAT Number: R004611
• CAS Number: 106941-25-7
• Molecular Formula: C8H12N5O4P
• Molecular Weight: 273.19
• Purity: ≥95%
• Synonyms: P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic Acid; 9-(2-Phosphonylmethoxyethyl)adenine; [[2-(6-Amino-9H-purin-9-yl)ethoxy]?methyl]phosponic Acid; GS 0393; PMEA; ??
• Storage: -20°C
• IUPAC Name: 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
• InChI: InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
• InChIKey: SUPKOOSCJHTBAH-UHFFFAOYSA-N
• SMILES: C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N

Adefovir（Cat No.:R004611）is an antiviral medication used primarily in the treatment of chronic hepatitis B. It functions by inhibiting the viral reverse transcriptase, preventing the replication of the hepatitis B virus (HBV). As a nucleotide analogue, Adefovir is phosphorylated within the body, leading to the inhibition of viral DNA synthesis. It is commonly used in patients with advanced liver disease, offering improved liver function and reduced viral load. However, it is associated with potential side effects, including nephrotoxicity, and requires monitoring during long-term use.