For research use only. Not for therapeutic Use.
Adelmidrol(CAT: I002191) emerges as a notable compound in the realm of anti-inflammatory agents and lipid-derived molecules. Serving as an ethanolamide derivative of azelaic acid, Adelmidrol presents a promising avenue for combating inflammation and related disorders. This compound’s structural resemblance to azelaic acid suggests its potential in modulating inflammatory pathways, which are often implicated in various pathological conditions.
| Catalog Number | I002191 |
| CAS Number | 1675-66-7 |
| Molecular Formula | C13H26N2O4 |
| Purity | ≥95% |
| Solubility | 10 mM in H2O |
| Storage | Store at -20°C |
| InChI | InChI=1S/C13H26N2O4/c16-10-8-14-12(18)6-4-2-1-3-5-7-13(19)15-9-11-17/h16-17H,1-11H2,(H,14,18)(H,15,19) |
| InChIKey | PAHZPHDAJQIETD-UHFFFAOYSA-N |
| SMILES | O=C(NCCO)CCCCCCCC(NCCO)=O |
| Reference | </br>1:Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. Di Paola R, Fusco R, Impellizzeri D, Cordaro M, Britti D, Morittu VM, Evangelista M, Cuzzocrea S.Arthritis Res Ther. 2016 Dec 12;18(1):291. PMID: 27955699 Free PMC Article</br>2:Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. Cordaro M, Impellizzeri D, Gugliandolo E, Siracusa R, Crupi R, Esposito E, Cuzzocrea S.Mol Pharmacol. 2016 Nov;90(5):549-561. Epub 2016 Sep 13. PMID: 27625036 </br>3:Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation. Impellizzeri D, Di Paola R, Cordaro M, Gugliandolo E, Casili G, Morittu VM, Britti D, Esposito E, Cuzzocrea S.Biochem Pharmacol. 2016 Nov 1;119:27-41. doi: 10.1016/j.bcp.2016.09.001. Epub 2016 Sep 4. PMID: 27599446 </br>4:Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis. Petrosino S, Puigdemont A, Della Valle MF, Fusco M, Verde R, Allarà M, Aveta T, Orlando P, Di Marzo V.Vet J. 2016 Jan;207:85-91. doi: 10.1016/j.tvjl.2015.10.060. Epub 2015 Nov 10. PMID: 26639824 </br>5:Effectiveness of vaginal adelmidrol for treating pelvic visceral discomforts and anxiety: a prospective observational study. Indraccolo U, Scutiero G, Matteo M, Greco P.Minerva Ginecol. 2013 Aug;65(4):465-70. PMID: 24051946 </br>6:Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis. Cerrato S, Brazis P, Della Valle MF, Miolo A, Puigdemont A.BMC Vet Res. 2012 Nov 26;8:230. doi: 10.1186/1746-6148-8-230. PMID: 23181761 Free PMC Article</br>7:Mast cell morphometry and densitometry in experimental skin wounds treated with a gel containing adelmidrol: a placebo controlled study. Abramo F, Salluzzi D, Leotta R, Auxilia S, Noli C, Miolo A, Mantis P, Lloyd DH.Wounds. 2008 Jun;20(6):149-57. PMID: 25942520 </br>8:Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. De Filippis D, D/’Amico A, Cinelli MP, Esposito G, Di Marzo V, Iuvone T.J Cell Mol Med. 2009 Jun;13(6):1086-95. doi: 10.1111/j.1582-4934.2008.00353.x. Epub 2008 Apr 18. PMID: 18429935 Free PMC Article</br>9:Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: a pilot study. Pulvirenti N, Nasca MR, Micali G.Acta Dermatovenerol Croat. 2007;15(2):80-3. PMID: 17631786 |
