Adenosine deaminase

• CAT Number: I019702
• CAS Number: 9026-93-1
• Molecular Formula: C83H165NO8P+
• Molecular Weight: 1336.20 g/mol
• Purity: ≥95%
• Target: Adenosine Deaminase
• IUPAC Name: 2-[(2-dotriacont-21-enoyloxy-3-tritetracontanoyloxypropoxy)-hydroxyphosphoryl]oxyethyl-trimethylazanium
• InChI: 1S/C83H164NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-37-38-39-40-41-42-43-44-45-46-48-49-51-53-55-57-59-61-63-65-67-69-71-73-75-82(85)89-79-81(80-91-93(87,88)90-78-77-84(3,4)5)92-83(86)76-74-72-70-68-66-64-62-60-58-56-54-52-50-47-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h25,27,81H,6-24,26,28-80H2,1-5H3/p+1
• InChIKey: XKSKQIORVXERAQ-UHFFFAOYSA-O
• SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCCCCC=CCCCCCCCCCC

Adenosine deaminase (ADA) (Cat No.: I019702) is a crucial enzyme involved in purine metabolism, catalyzing the deamination of adenosine to inosine. It plays a vital role in maintaining immune function, particularly in the development and maintenance of lymphocytes. ADA deficiency leads to severe combined immunodeficiency (SCID), highlighting its physiological importance. Clinically, ADA activity is used as a diagnostic marker for certain diseases, including tuberculosis and leukemia. It is also a target in drug development for immune-related and metabolic disorders due to its regulatory functions.

Reference

[1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234.[2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823.