For research use only. Not for therapeutic Use.
Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM)[1]. Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research[1][2].
Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 μM with producing 50% inhibition[2].
Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals[3].Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice[3].Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[3].
| Catalog Number | I011623 |
| CAS Number | 34240-05-6 |
| Synonyms | 2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal |
| Molecular Formula | C10H11N5O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13) |
| InChIKey | ILMNSCQOSGKTNZ-UHFFFAOYSA-N |
| SMILES | C1=NC(=C2C(=N1)N(C=N2)C(C=O)OC(CO)C=O)N |
| Reference | [1]. V Ramakrishnan, et al. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells. Neurochem Int. 1987;10(4):423-31. [2]. G V Madhavan, et al. Synthesis and antiviral evaluation of 6′-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem [3]. B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48(21):5933-6. |
