Adenylyl cyclase type 2 agonist-1

• CAT Number: I043551
• CAS Number: 2414908-52-2
• Molecular Formula: C27H17BrClNO5
• Molecular Weight: 550.78
• Purity: ≥95%
• Synonyms: (1S,3aS,6aR)-5′-bromo-5-(2-chlorophenyl)-1-(4-methylphenyl)spiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2′-indene]-1′,3′,4,6-tetrone
• InChI: InChI=1S/C27H17BrClNO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)19-5-3-2-4-18(19)29)27(35-22)23(31)16-11-10-15(28)12-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1
• InChIKey: HVCLMGZGIMRDRV-LPOKKUQKSA-N
• SMILES: CC1=CC=C(C=C1)C2C3C(C(=O)N(C3=O)C4=CC=CC=C4Cl)C5(O2)C(=O)C6=C(C5=O)C=C(C=C6)Br

Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases[1].

Reference

[1]. Guowei Xu, et al. The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. Eur J Med Chem. 2020 Apr 1;191:112115.
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