For research use only. Not for therapeutic Use.
ADEP4 (Cat No.:I021392) is a small molecule that activates the ClpP protease, a key component in bacterial protein degradation. By binding to ClpP, ADEP4 induces uncontrolled proteolysis, disrupting bacterial homeostasis and leading to cell death. This compound is particularly effective against Gram-positive bacteria, including drug-resistant strains like Staphylococcus aureus. ADEP4 acts independently of ClpX, the usual cofactor required for ClpP activation, making it a promising candidate for the development of novel antibacterial therapies, particularly against resistant infections.
| Catalog Number | I021392 |
| Synonyms | ADEP4; ADEP-4; ADEP 4 |
| Molecular Formula | C39H52F2N6O8 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (E)-N-[(2S)-3-(3,5-difluorophenyl)-1-[[(3S,9S,13S,15R,19S,22S)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetrazatetracyclo[20.4.0.03,7.013,17]hexacosan-9-yl]amino]-1-oxopropan-2-yl]hept-2-enamide |
| InChI | InChI=1S/C39H52F2N6O8/c1-4-5-6-7-13-33(48)43-28(19-25-17-26(40)20-27(41)18-25)34(49)44-29-22-55-39(54)32-16-23(2)21-47(32)36(51)24(3)42-35(50)30-11-8-9-14-45(30)38(53)31-12-10-15-46(31)37(29)52/h7,13,17-18,20,23-24,28-32H,4-6,8-12,14-16,19,21-22H2,1-3H3,(H,42,50)(H,43,48)(H,44,49)/b13-7+/t23-,24+,28+,29+,30+,31+,32+/m1/s1 |
| InChIKey | BAEUBYUDIYWBPI-HQKUAFLWSA-N |
| SMILES | CCCC/C=C/C(=O)N[C@@H](CC1=CC(=CC(=C1)F)F)C(=O)N[C@H]2COC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CCCCN4C(=O)[C@@H]5CCCN5C2=O)C)C |
