For research use only. Not for therapeutic Use.
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor.
Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells[1][2][3].
Adrenosterone markedly decreases Snail and Slug expression in HCCLM3 and MDA-MB-231 cells. Adrenosterone suppresses cell motility and invasion of highly metastatic human cancer cells (HCCLM3, MDA-MB-231, and MDA-MB-435 cells)[1].
Adrenosterone is a competitive inhibitor of HSD11β1, which catalyzes the interconversion of the steroid pair of the inactive metabolite cortisone and the stress hormone cortisol. Adrenosterone decreases the amount of cortisol[1].
| Catalog Number | I003407 |
| CAS Number | 382-45-6 |
| Synonyms | (8S,9S,10R,13S,14S)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11,17-trione |
| Molecular Formula | C19H24O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H24O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-14,17H,3-8,10H2,1-2H3/t13-,14-,17+,18-,19-/m0/s1 |
| InChIKey | RZRPTBIGEANTGU-IRIMSJTPSA-N |
| SMILES | CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4=O)C |
| Reference | [1]. Joji Nakayama, et al. A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial-Mesenchymal Transition and Metastatic Dissemination. Mol Cancer Res. 2020 Mar;18(3):477-487. [2]. Brooker L, et al. Carbon isotope ratio analysis of endogenous glucocorticoid urinary metabolites after cortisone acetate andadrenosterone administration for doping control. Drug Test Anal. 2012 Dec;4(12):951-61. [3]. Choudhary MI, et al. Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans. Steroids. 2007 Dec;72(14):923-9. |
