ADX-88178

• CAT Number: I010180
• CAS Number: 1235318-89-4
• Molecular Formula: C12H12N6S
• Molecular Weight: 272.33
• Purity: ≥95%
• Synonyms: 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
• Target: Neuronal Signaling
• Storage: Store at +4C
• IUPAC Name: 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
• InChI: InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
• InChIKey: MIQNXKWDQRNHAU-UHFFFAOYSA-N
• SMILES: CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3

ADX-88178 (CAT: I010180) is a novel, potent, and selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4), characterized by its brain-penetrant properties. It has demonstrated efficacy in rodent models of anxiety, obsessive-compulsive disorder (OCD), fear, depression, and psychosis. In behavioral tests, ADX-88178 dose-dependently reduced the number of buried marbles in the marble burying test, indicative of anti-compulsive effects, and increased open-arm exploration in the elevated plus maze (EPM) test, suggesting anxiolytic-like activity. This compound is a valuable tool in neuropsychiatric research, offering insights into mGlu4 modulation as a therapeutic strategy for psychiatric and mood disorders.