ADX-88178

• CAT Number: I010180
• CAS Number: 1235318-89-4
• Molecular Formula: C12H12N6S
• Molecular Weight: 272.33
• Purity: ≥95%
• Synonyms: 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
• Target: Neuronal Signaling
• Storage: Store at +4C
• IUPAC Name: 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
• InChI: InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
• InChIKey: MIQNXKWDQRNHAU-UHFFFAOYSA-N
• SMILES: CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3

ADX-88178(cas 1235318-89-4) is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.

Reference

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Browne SE, Uslaner JM, Davis MJ, Raber J, Duvoisin R, Bate ST, Reynolds IJ, Poli
S, Celanire S. Characterization of the novel positive allosteric modulator of the
metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric
disorders. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505. doi:
10.1124/jpet.114.214437. Epub 2014 Jun 19. PubMed PMID: 24947466; PubMed Central
PMCID: PMC4152882.

2: Ponnazhagan R, Harms AS, Thome AD, Jurkuvenaite A, Gogliotti R, Niswender CM,
Conn PJ, Standaert DG. The Metabotropic Glutamate Receptor 4 Positive Allosteric
Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. J
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Zhang Y, Kawamura K, Zhang MR. Radiosynthesis and evaluation of
5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine
([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate
receptor subtype 4 (mGluR4). Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4. doi:
10.1016/j.bmcl.2015.12.008. Epub 2015 Dec 7. PubMed PMID: 26707390.