AE-ITU dihydrobromide

• CAT Number: I011638
• CAS Number: 56-10-0
• Molecular Formula: C3H11Br2N3S
• Molecular Weight: 281.01
• Purity: ≥95%
• Synonyms: 2-aminoethyl carbamimidothioate;dihydrobromide
• InChI: InChI=1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H
• InChIKey: XDVMCVGTDUKDHL-UHFFFAOYSA-N
• SMILES: C(CSC(=N)N)N.Br.Br

AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats[1].
AE-ITU dihydrobromide (1 mg/kg/h, i.v., for 1 hour) attenuates the delayed hypotension and vascular hyporeactivity, ameliorates liver dysfunction in LPS (HY-D1056)-administrated Wistar rats[1].

Reference

[1]. Thiemermann C, et al., The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol. 1995 Dec;116(7):2845-51.
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