AEBSF.HCl

• CAT Number: I003091
• CAS Number: 30827-99-7
• Molecular Formula: C₈H₁₀FNO₂S.HCl
• Molecular Weight: 239.69
• Purity: ≥95%
• Synonyms: 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
• Target: Serine Protease
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: 2-8°C
• InChI: InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
• InChIKey: WRDABNWSWOHGMS-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl

AEBSF hydrochloride（Cat No.:I003091） is an irreversible inhibitor commonly used to inhibit serine proteases, including chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. As a serine protease inhibitor, AEBSF hydrochloride forms a covalent bond with the active site serine residue of these enzymes, irreversibly inactivating them. By blocking the activity of serine proteases, AEBSF hydrochloride is utilized in various research applications and laboratory experiments where the specific inhibition of serine proteases is desired, allowing for the investigation of their roles in physiological and pathological processes.

Reference

[1]. Powers JC, et al. Irreversible inhibitors of serine, cysteine, and threonine proteases. Chem Rev. 2002 Dec;102(12):4639-750.
[2]. GOLD AM, et al. SULFONYL FLUORIDES AS INHIBITORS OF ESTERASES. II. FORMATION AND REACTIONS OF PHENYLMETHANESULFONYL ALPHA-CHYMOTRYPSIN. Biochemistry. 1964 Jun;3:783-91.