For research use only. Not for therapeutic Use.
AEE-788 (Cat.No:I003750) is a small-molecule inhibitor of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) tyrosine kinases. It is being studied as a potential treatment for various types of cancer. AEE-788 has shown promising results in preclinical studies and is currently undergoing clinical trials to assess its safety and efficacy.
| Catalog Number | I003750 |
| CAS Number | 497839-62-0 |
| Synonyms | 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Molecular Formula | C₂₇H₃₂N₆ |
| Purity | ≥95% |
| Target | Protein Tyrosine Kinase/RTK |
| Solubility | DMSO 88 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
| Storage | 3 years -20℃ powder |
| IC50 | 2 nM( EGFR); 6 nM (ErbB2) |
| IUPAC Name | 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| InChI | InChI=1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)/t20-/m1/s1 |
| InChIKey | OONFNUWBHFSNBT-HXUWFJFHSA-N |
| SMILES | CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4NC(C)C5=CC=CC=C5 |
