Aeide-C1-NHS ester

• CAT Number: I015837
• CAS Number: 824426-32-6
• Molecular Formula: C6H6N4O4
• Molecular Weight: 198.14
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 2-azidoacetate
• InChI: InChI=1S/C6H6N4O4/c7-9-8-3-6(13)14-10-4(11)1-2-5(10)12/h1-3H2
• InChIKey: FENNDBOWHRZLTQ-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CN=[N+]=[N-]

Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aeide-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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