For research use only. Not for therapeutic Use.
AFDX384 is a bioactive chemical.
| Catalog Number | M016377 |
| CAS Number | 118290-27-0 |
| Molecular Formula | C27H38N6O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | Store at +4C |
| InChI | InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34) |
| InChIKey | MZDYABXXPZNUCT-UHFFFAOYSA-N |
| SMILES | O=C(N1C2=NC=CC=C2NC(C3=CC=CC=C31)=O)NCCN4C(CN(CCC)CCC)CCCC4 |
| Reference | </br>1:Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84. Mohr M, Heller E, Ataie A, Mohr K, Holzgrabe U.J Med Chem. 2004 Jun 3;47(12):3324-7. PMID: 15163212 </br>2:Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain. Piggott M, Owens J, O/’Brien J, Paling S, Wyper D, Fenwick J, Johnson M, Perry R, Perry E.J Chem Neuroanat. 2002 Sep;24(3):211-23. PMID: 12297267 </br>3:Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors. Martin J, Deagostino A, Perrio C, Dauphin F, Ducandas C, Morin C, Desbène PL, Lasne MC.Bioorg Med Chem. 2000 Mar;8(3):591-600. PMID: 10732976 </br>4:The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia. Crook JM, Dean B, Pavey G, Copolov D.Life Sci. 1999;64(19):1761-71. PMID: 10353630 </br>5:M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site. Tränkle C, Andresen I, Lambrecht G, Mohr K.Mol Pharmacol. 1998 Feb;53(2):304-12. PMID: 9463489 Free Article</br>6:In vivo binding, pharmacokinetics and metabolism of the selective M2 muscarinic antagonists [3H]AF-DX 116 and [3H]AF-DX 384 in the anesthetized rat. Mickala P, Boutin H, Bellanger C, Chevalier C, MacKenzie ET, Dauphin F.Nucl Med Biol. 1996 Feb;23(2):173-9. PMID: 8868291 </br>7:AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. Dopke KL, Vrana KE, Vogt LJ, Vogt BA.J Pharmacol Exp Ther. 1995 Jul;274(1):562-9. PMID: 7616446 </br>8:Characterization and autoradiographic distribution of [3H]AF-DX 384 binding to putative muscarinic M2 receptors in the rat brain. Aubert I, Cécyre D, Gauthier S, Quirion R.Eur J Pharmacol. 1992 Jul 7;217(2-3):173-84. PMID: 1425938 </br>9:Muscarinic M2 receptors in rat brain labeled with [3H] AF-DX 384. Castoldi AF, Fitzgerald B, Manzo L, Tonini M, Costa LG.Res Commun Chem Pathol Pharmacol. 1991 Dec;74(3):371-4. PMID: 1775727 </br>10:Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. Miller JH, Gibson VA, McKinney M.J Pharmacol Exp Ther. 1991 Nov;259(2):601-7. PMID: 1941609 |
