AF38469

• CAT Number: I001914
• CAS Number: 1531634-31-7
• Molecular Formula: C15H11F3N2O3
• Molecular Weight: 324.25
• Purity: ≥95%
• Target: Sortilin inhibitor
• Solubility: DMSO: ≥ 43 mg/mL
• Storage: Store at -20C
• IC50: 330 nM [1]
• IUPAC Name: 2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid
• InChI: InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
• InChIKey: JWCUSQCZMQIBMR-UHFFFAOYSA-N

AF38469 (CAT: I001914) is an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin, with an IC50 of 330 nM. AF38469 has shown no significant inhibition or stimulation of over 50 targets in a standard selectivity panel, including the NTR1 receptor and a panel of targets known to bind acidic molecules such as d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, and MMP-12. This compound can be a valuable tool for studying the biology of Sortilin and evaluating its therapeutic potential.

Reference

1. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80.