For research use only. Not for therapeutic Use.
AF64394（Cat No.:I019787）is a positive allosteric modulator of the acid-sensing ion channel 1a (ASIC1a), a key receptor involved in pain perception and neuroprotection. By enhancing the activity of ASIC1a, AF64394 has shown potential in research focused on neurological disorders, including ischemia, chronic pain, and neurodegenerative diseases. Its ability to modulate ASIC1a signaling has made it a valuable tool in exploring the role of these channels in central nervous system function and pathology.
| Catalog Number | I019787 |
| CAS Number | 1637300-25-4 |
| Molecular Formula | C₂₁H₂₀ClN₅O |
| Purity | ≥95% |
| Storage | 2-8°C |
| IUPAC Name | N-[(4-chloro-2-propan-2-yloxyphenyl)methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine |
| InChI | InChI=1S/C21H20ClN5O/c1-14(2)28-19-10-17(22)9-8-16(19)12-23-20-11-18(15-6-4-3-5-7-15)26-21-24-13-25-27(20)21/h3-11,13-14,23H,12H2,1-2H3 |
| InChIKey | WBYNZQXAAWPAGR-UHFFFAOYSA-N |
| SMILES | CC(C)OC1=C(C=CC(=C1)Cl)CNC2=CC(=NC3=NC=NN23)C4=CC=CC=C4 |
| Reference | [1]. Jensen T, et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5195-8. |
