Afatinib

• CAT Number: I005096
• CAS Number: 850140-72-6
• Molecular Formula: C24H25ClFN5O3
• Molecular Weight: 485.94
• Purity: ≥95%
• Target: EGFR;EGFR mutant forms; HER2
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.5 nM/0.4 nM/10 nM/14 nM (EGFR(wt)/EGFR(L858R)/EGFR(L858R/T790M) /HER2) [1]
• IUPAC Name: (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
• InChI: InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
• InChIKey: ULXXDDBFHOBEHA-CWDCEQMOSA-N
• SMILES: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Afatinib (Cat.No:I005096) is a tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer with certain mutations of the epidermal growth factor receptor (EGFR). It works by blocking signals that promote cancer cell growth and division. 

Reference

[1]. D Li et al BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models Oncogene (2008) 27, 4702-4711
[2]. Ioannou N, et al. Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells. BMC Cancer. 2013 Jan 31;13:41.