Afatinib impurity 11

• CAT Number: I014281
• CAS Number: 1402086-20-7
• Molecular Formula: C₂₁H₁₈ClFN₄O₃
• Molecular Weight: 428.84
• Purity: ≥95%
• Target: Protein Tyrosine Kinase/RTK
• Storage: Store at -20°C
• IUPAC Name: N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]prop-2-enamide
• InChI: InChI=1S/C21H18ClFN4O3/c1-2-20(28)27-18-8-14-17(9-19(18)30-13-5-6-29-10-13)24-11-25-21(14)26-12-3-4-16(23)15(22)7-12/h2-4,7-9,11,13H,1,5-6,10H2,(H,27,28)(H,24,25,26)/t13-/m0/s1
• InChIKey: MLHDLQIHGCIPJQ-ZDUSSCGKSA-N
• SMILES: C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Afatinib impurity 11（Cat No.:I014281） is an impurity derived from Afatinib, an irreversible inhibitor of the EGFR (epidermal growth factor receptor) family. Afatinib has potent inhibitory activity against EGFRwt, EGFRL858R, EGFRL858R/T790M, and HER2, with IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively. Afatinib impurity 11 refers to a specific chemical impurity present in Afatinib. The presence of impurities in drug substances is monitored and controlled to ensure the quality and safety of the pharmaceutical product.