For research use only. Not for therapeutic Use.
Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is an orally active mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1][2][3].
Aflatoxin M1 (0.5, 1 μg/mL, 24-72 h) inhibits the growth of Caco-2 cells in a time dose-dependent manner [2].
Aflatoxin M1 (3.5g /kg, gavage once a day for 28 days) activates oxidative stress by altering the expression of PRODH and L-proline, and then induces apoptosis of downstream cells of CD-1 mice, thereby causing renal toxicity[3].
| Catalog Number | R010782 |
| CAS Number | 6795-23-9 |
| Synonyms | 3-hydroxy-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione |
| Molecular Formula | C17H12O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H12O7/c1-21-9-6-10-13(17(20)4-5-22-16(17)23-10)14-12(9)7-2-3-8(18)11(7)15(19)24-14/h4-6,16,20H,2-3H2,1H3 |
| InChIKey | MJBWDEQAUQTVKK-UHFFFAOYSA-N |
| SMILES | COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C(=C1)OC5C4(C=CO5)O |
| Reference | [1]. Kumar P, et al. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Front Microbiol. 2017 Jan 17;7:2170. [2]. Zhang J, et al. Aflatoxin B1 and aflatoxin M1 induced cytotoxicity and DNA damage in differentiated and undifferentiated Caco-2 cells. Food Chem Toxicol. 2015 Sep;83:54-60. [3]. Li H, et al. The Toxic Effects of Aflatoxin B1 and Aflatoxin M1 on Kidney through Regulating L-Proline and Downstream Apoptosis. Biomed Res Int. 2018 Aug 12;2018:9074861. |
