Afloqualone

• CAT Number: I004100
• CAS Number: 56287-74-2
• Molecular Formula: C16H14FN3O
• Molecular Weight: 283.3
• Purity: ≥95%
• Target: GABA Receptor
• Solubility: DMSO:33mg/mL
• Storage: Store at 4°C
• IUPAC Name: 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
• InChI: InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3
• InChIKey: VDOSWXIDETXFET-UHFFFAOYSA-N
• SMILES: CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF

Afloqualone (Cat.No:I004100) is a quinazolinone derivative that acts as a central nervous system depressant. It was used as a sedative and muscle relaxant, but due to its potential for abuse and dependence, it is no longer used in clinical practice. It acts as a GABA-A receptor agonist and has similar effects to barbiturates.

Reference

[1]. Yamamura M, et al. Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author/’s transl). Nihon Yakurigaku Zasshi. 1981 Oct;78(4):381-92.