Afoxolaner

• CAT Number: I001327
• CAS Number: 1093861-60-9
• Molecular Formula: C26H17ClF9N3O3
• Molecular Weight: 625.88
• Purity: ≥95%
• Synonyms: Afoxolaner, Trade name: NexGard.;4-(5-(3-Chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)naphthalene-1-carboxamide
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
• IUPAC Name: 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide
• InChI: InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)
• InChIKey: OXDDDHGGRFRLEE-UHFFFAOYSA-N
• SMILES: C1C(=NOC1(C2=CC(=CC(=C2)Cl)C(F)(F)F)C(F)(F)F)C3=CC=C(C4=CC=CC=C43)C(=O)NCC(=O)NCC(F)(F)F

Afoxolaner（Cat No.:I001327）is a powerful ectoparasiticide used in veterinary medicine to control and prevent flea and tick infestations in dogs. As an isoxazoline-class compound, it works by inhibiting the GABA-gated chloride channels in parasites, leading to their paralysis and death. Administered orally, Afoxolaner provides long-lasting protection, typically up to one month, ensuring effective management of flea allergy dermatitis and tick-borne diseases. Its safety and efficacy make it a popular choice among pet owners and veterinarians, ensuring pets remain healthy and free from harmful parasites.