For research use only. Not for therapeutic Use.
AFP464 (dihydrochloride) (NSC710464 (dihydrochloride)) is the hydrochloride form of AFP464 and is a potent HIF-1α inhibitor with an IC50 value of 0.25 μM. It is also an activator of aryl hydrocarbon receptor (AhR).
| Catalog Number | I040212 |
| Synonyms | (2S)-2,6-diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;dihydrochloride |
| Molecular Formula | C22H25Cl2F3N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H23F3N4O3.2ClH/c1-10-18(24)20(28)17-15(30)9-16(32-21(17)19(10)25)11-5-6-14(12(23)8-11)29-22(31)13(27)4-2-3-7-26;;/h5-6,8-9,13H,2-4,7,26-28H2,1H3,(H,29,31);2*1H/t13-;;/m0../s1 |
| InChIKey | KWQPRUCXYQBCLR-GXKRWWSZSA-N |
| SMILES | CC1=C(C(=C2C(=O)C=C(OC2=C1F)C3=CC(=C(C=C3)NC(=O)C(CCCCN)N)F)N)F.Cl.Cl |
| Reference | [1]. Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70(17):6837-48. |
