AG-014699 phosphate

• CAT Number: I003606
• CAS Number: 459868-92-9
• Molecular Formula: C₁₉H₂₁FN₃O₅P
• Molecular Weight: 421.36
• Purity: ≥95%
• Synonyms: 8-fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate
• Target: Epigenetics
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: 3 years -20C powder
• IC50: 1.4 nM (Ki)
• IUPAC Name: 6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one;phosphoric acid
• InChI: InChI=1S/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4)
• InChIKey: FCCGJTKEKXUBFZ-UHFFFAOYSA-N
• SMILES: CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2.OP(=O)(O)O

AG-014699 phosphate（Cat No.:I003606）, also known as Rucaparib phosphate, is a potent PARP (poly ADP-ribose polymerase) inhibitor. It works by inhibiting the PARP enzyme, which is involved in DNA repair, particularly single-strand break repair. By blocking PARP activity, AG-014699 induces synthetic lethality in cancer cells with deficient homologous recombination repair, such as BRCA1 or BRCA2 mutations, leading to cell death. This makes it a valuable therapeutic in cancer treatment, particularly for ovarian and breast cancers. Its phosphate form improves solubility and bioavailability for clinical applications in oncology.