For research use only. Not for therapeutic Use.
AG-045572（Cat No.:I010616）is a selective inhibitor of the protein tyrosine kinase called FLT3, which plays a significant role in the proliferation and survival of hematopoietic cells. This small molecule is primarily studied for its potential use in treating acute myeloid leukemia (AML) and other hematologic malignancies, where FLT3 mutations are common. AG-045572 works by blocking FLT3 signaling, which disrupts cancer cell growth and survival. Preclinical studies have shown promising results, and ongoing research aims to evaluate its safety, efficacy, and potential as a targeted therapy for AML and other blood cancers.
| CAS Number | 263847-55-8 |
| Synonyms | 5-[(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)methyl]-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide |
| Molecular Formula | C30H37NO5 |
| Purity | ≥95% |
| IUPAC Name | 5-[(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)methyl]-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide |
| InChI | InChI=1S/C30H37NO5/c1-18-13-22-23(30(4,5)12-11-29(22,2)3)15-19(18)14-20-9-10-24(36-20)28(32)31-27-25(34-7)16-21(33-6)17-26(27)35-8/h9-10,13,15-17H,11-12,14H2,1-8H3,(H,31,32) |
| InChIKey | IPEMCIBPDYCJLO-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1CC3=CC=C(O3)C(=O)NC4=C(C=C(C=C4OC)OC)OC)C(CCC2(C)C)(C)C |
