AG 18

• CAT Number: I000649
• CAS Number: 118409-57-7
• Molecular Formula: C10H6N2O2
• Molecular Weight: 186.10
• Purity: ≥95%
• Synonyms: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile
• Target: Protein Tyrosine Kinase/RTK
• Solubility: DMSO: ≥ 50 mg/mL
• Storage: 3 years -20C powder
• IC50: 40 uM (inhibition of EGFR autophosphorylation)[1]
• InChI: InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
• InChIKey: VTJXFTPMFYAJJU-UHFFFAOYSA-N
• SMILES: N#CC(=Cc1ccc(O)c(O)c1)C#N

AG 18 (Cat No.: I000649) is a tyrosine kinase inhibitor that primarily targets receptor tyrosine kinases (RTKs), including the epidermal growth factor receptor (EGFR). By inhibiting tyrosine kinase activity, AG 18 disrupts key signaling pathways involved in cell proliferation, differentiation, and survival. It is widely used in cancer research to study growth factor-mediated signaling and tumor progression. Additionally, AG 18 has applications in angiogenesis and inflammation research. As a valuable biochemical tool, it aids in investigating kinase-dependent cellular processes and potential therapeutic targets.

Reference

1:Reactions of a cyclodimethylsiloxane (Me2SiO)6 with silver salts of weakly coordinating anions; crystal structures of [Ag(Me2SiO)6][Al] ([Al] = [FAl{OC(CF3)3}3], [Al{OC(CF3)3}4]) and their comparison with [Ag(18-crown-6)]2[SbF6]2. Cameron TS, Decken A, Krossing I, Passmore J, Rautiainen JM, Wang X, Zeng X.Inorg Chem. 2013 Mar 18;52(6):3113-26. doi: 10.1021/ic3025793. Epub 2013 Feb 27. PMID: 23445274 2:Electronic structure of the mononuclear Ag(ii) complex [Ag([18]aneS(4)O(2))](2+) ([18]aneS(4)O(2) = 1,10-dioxa-4,7,13,16-tetrathiacyclooctadecane). Huang D, Blake AJ, McInnes EJ, McMaster J, Davies ES, Wilson C, Wolowska J, Schröder M.Chem Commun (Camb). 2008 Mar 21;(11):1305-7. doi: 10.1039/b717647c. Epub 2008 Jan 17. PMID: 18389115