For research use only, not for therapeutic use.
AG1024 (Cat No.:I004477), also known as Tyrphostin AG1024 or NVP-AG1024, is a small molecule inhibitor that specifically targets and inhibits the insulin-like growth factor 1 receptor (IGF-1R). It acts by binding to the ATP-binding site of IGF-1R, preventing its activation and subsequent signaling pathways. By inhibiting IGF-1R, AG1024 can impede the growth and survival of cancer cells that rely on IGF-1R signaling for their proliferation. AG1024 has been investigated for its potential in cancer therapy, particularly in cancers driven by aberrant IGF-1R signaling, and it shows promise as a targeted therapeutic agent for certain types of cancer.
| Catalog Number | I004477 |
| CAS Number | 65678-07-1 |
| Synonyms | 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| Molecular Formula | C14H13BrN2O |
| Purity | ≥95% |
| Target | IGF1R |
| Solubility | DMSO 61 mg/ml; Water <1 mg/ml |
| Storage | 3 years -20C powder |
| IC50 | 7 uM (IGF-1R autophosphorylation); 57 uM (IR) |
| IUPAC Name | 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| InChI | InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3 |
| InChIKey | ABBADGFSRBWENF-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O |
| Reference | 1:Effects of insulin-like growth factor 1 receptor and its inhibitor AG1024 on the progress of lung cancer. Wei YH, Tang HX, Liao YD, Fu SL, Xu LQ, Chen G, Zhang C, Ju S, Liu ZG, You LK, Yu L, Zhou S.J Huazhong Univ Sci Technolog Med Sci. 2015 Dec;35(6):834-41. doi: 10.1007/s11596-015-1515-1. Epub 2015 Dec 16. PMID: 26670433 <br /> |
