AG14361

• CAT Number: I003166
• CAS Number: 328543-09-5
• Molecular Formula: C19H20N4O
• Molecular Weight: 320.39
• Purity: ≥95%
• Synonyms: 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one
• Target: Epigenetics
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: 3 years -20C powder
• IC50: <5 nM( Ki)
• IUPAC Name: 2-[4-[(dimethylamino)methyl]phenyl]-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-9-one
• InChI: InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
• InChIKey: SEKJSSBJKFLZIT-UHFFFAOYSA-N
• SMILES: O=C1C2=C3C(N=C(C4=CC=C(CN(C)C)C=C4)N3CCN1)=CC=C2

AG14361(CAT: I003166) is a highly potent and selective inhibitor of Poly (ADP-ribose) polymerase 1 (PARP1) with a Ki of <5 nM. PARP1 is a critical enzyme involved in DNA repair, particularly in the base excision repair (BER) pathway. By inhibiting PARP1, AG14361 prevents the repair of single-strand DNA breaks, leading to the accumulation of DNA damage and subsequent cell death, especially in cancer cells with deficient DNA repair mechanisms (e.g., BRCA1/2 mutations). AG14361 is extensively used in oncology research to explore targeted cancer therapies and combination treatments that exploit DNA damage response vulnerabilities in tumors.