For research use only. Not for therapeutic Use.
AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194[1][2].
| Catalog Number | I001487 |
| CAS Number | 189290-58-2 |
| Synonyms | N-(3-iodophenyl)-6,7-dimethoxyquinazolin-4-amine |
| Molecular Formula | C16H14IN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14IN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) |
| InChIKey | FGCLAQLIXMAIHT-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)I)OC |
| Reference | [1]. Akshada Joshi, et al. Identification of Potential Novel EGFR Inhibitors using a Combination of Pharmacophore and Docking Methods. International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491 Vol 7, Issue 6, 2015 [2]. Ellis AG, et al. High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma. J Chromatogr B Biomed Sci Appl. 2001 Apr 15;754(1):193-9. |
