AGN 194078

• CAT Number: I020312
• CAS Number: 321995-62-4
• Molecular Formula: C₂₂H₂₃F₂NO₄
• Molecular Weight: 403.42
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid
• InChI: InChI=1S/C22H23F2NO4/c1-21(2)5-6-22(3,4)14-10-17(26)12(9-13(14)21)19(27)25-11-7-15(23)18(20(28)29)16(24)8-11/h7-10,26H,5-6H2,1-4H3,(H,25,27)(H,28,29)
• InChIKey: BCKLKOYFMACAMZ-UHFFFAOYSA-N
• SMILES: CC1(CCC(C2=C1C=C(C(=C2)O)C(=O)NC3=CC(=C(C(=C3)F)C(=O)O)F)(C)C)C

AGN 194078（Cat No.:I020312）is a selective retinoic acid receptor (RAR) antagonist, primarily targeting RAR-γ with high affinity. By inhibiting this receptor, AGN 194078 modulates retinoid signaling pathways, which play crucial roles in cell differentiation, proliferation, and apoptosis. This compound is extensively used in dermatology and oncology research to explore its effects on skin disorders, cancer, and conditions influenced by retinoid activity. Its specificity for RAR-γ allows researchers to study receptor-selective mechanisms, offering potential for developing targeted therapies with reduced side effects in retinoid-based treatments.

Reference

[1]. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.