For research use only. Not for therapeutic Use.
AGN 194310（Cat No.:I002752）is a synthetic retinoid and selective retinoic acid receptor (RAR) agonist with a high affinity for the RARβ and RARγ subtypes. It promotes cell differentiation and growth regulation, making it valuable in dermatological and oncology research. AGN 194310 has shown promise in skin renewal applications, supporting studies on acne, psoriasis, and photoaging. Additionally, its role in inducing differentiation has sparked interest in cancer research, where it’s used to explore retinoid-based therapies that target abnormal cell proliferation. This compound is essential for studying RAR-mediated biological processes.
| Catalog Number | I002752 |
| CAS Number | 229961-45-9 |
| Synonyms | 4-((4-(4-ethylphenyl)-2,2-dimethyl-2H-thiochromen-6-yl)ethynyl)benzoic acid |
| Molecular Formula | C28H24O2S |
| Purity | ≥95% |
| Target | RAR/RXR |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 3/2/5 nM (Kd for RARα/β/γ) |
| IUPAC Name | 4-[2-[4-(4-ethylphenyl)-2,2-dimethylthiochromen-6-yl]ethynyl]benzoic acid |
| InChI | InChI=1S/C28H24O2S/c1-4-19-7-12-22(13-8-19)25-18-28(2,3)31-26-16-11-21(17-24(25)26)6-5-20-9-14-23(15-10-20)27(29)30/h7-18H,4H2,1-3H3,(H,29,30) |
| InChIKey | LHUPKWKWYWOMSK-UHFFFAOYSA-N |
| SMILES | CCC1=CC=C(C=C1)C2=CC(SC3=C2C=C(C=C3)C#CC4=CC=C(C=C4)C(=O)O)(C)C |
| Reference | <p style=/line-height:25px/> <br>[2]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. <br>[3]. Austenaa LM, et al. Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging. FASEB J. 2004 Aug;18(11):1255-7. <br>[4]. Walkley CR, et al. Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia. 2002 Sep;16(9):1763-72. </p> |
