AGN 196996

• CAT Number: I005684
• CAS Number: 958295-17-5
• Molecular Formula: C24H20BrNO5
• Molecular Weight: 482.33
• Purity: ≥95%
• Synonyms: AGN196996;AGN-196996
• Target: RAR/RXR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 2 nM(Ki)
• IUPAC Name: 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]benzoic acid
• InChI: InChI=1S/C24H20BrNO5/c1-3-31-22-19(21(27)15-6-4-14(2)5-7-15)12-17(13-20(22)25)23(28)26-18-10-8-16(9-11-18)24(29)30/h4-13H,3H2,1-2H3,(H,26,28)(H,29,30)
• InChIKey: BUGXGZOGQGUTBC-UHFFFAOYSA-N
• SMILES: CCOC1=C(C=C(C=C1Br)C(=O)NC2=CC=C(C=C2)C(=O)O)C(=O)C3=CC=C(C=C3)C

AGN 196996（Cat No.:I005684）is a selective androgen receptor modulator (SARM) designed to target androgen receptors with minimal effects on non-target tissues. It shows anabolic activity, promoting muscle and bone health while reducing the risks associated with traditional androgen therapies. By selectively binding to androgen receptors, AGN 196996 stimulates muscle growth and improves physical performance, making it valuable in research on muscle-wasting diseases and osteoporosis. Its tissue-selective action minimizes common androgenic side effects, supporting its potential in developing safer therapeutic options for conditions requiring androgen receptor activation.

Reference

[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. 





[2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.