AGN 205728

• CAT Number: I005160
• CAS Number: 859498-05-8
• Molecular Formula: C29H27NO3
• Molecular Weight: 437.54
• Purity: ≥95%
• Synonyms: 4-((1E,3Z)-3-(8,8-dimethyl-5-(p-tolyl)-7,8-dihydronaphthalen-2-yl)-3-(hydroxyimino)prop-1-en-1-yl)benzoic acid
• Target: RAR/RXR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 3 nM/ 0.6 nM(Ki/IC95)
• IUPAC Name: 4-[(E,3E)-3-[8,8-dimethyl-5-(4-methylphenyl)-7H-naphthalen-2-yl]-3-hydroxyiminoprop-1-enyl]benzoic acid
• InChI: InChI=1S/C29H27NO3/c1-19-4-9-21(10-5-19)24-16-17-29(2,3)26-18-23(13-14-25(24)26)27(30-33)15-8-20-6-11-22(12-7-20)28(31)32/h4-16,18,33H,17H2,1-3H3,(H,31,32)/b15-8+,30-27+
• InChIKey: AUKGBKLQWDXBEP-FSLFYVJCSA-N
• SMILES: CC1=CC=C(C=C1)C2=CCC(C3=C2C=CC(=C3)/C(=N/O)/C=C/C4=CC=C(C=C4)C(=O)O)(C)C

AGN 205728（Cat No.:I005160）is a selective antagonist of the melanocortin-5 receptor (MC5R), a receptor involved in various physiological processes, including lipid metabolism, immune response, and exocrine gland function. By targeting MC5R, AGN 205728 has been explored for its potential to modulate inflammatory responses and lipid regulation, making it relevant in research on skin disorders, metabolic conditions, and inflammation. Its selective inhibition of MC5R also holds promise for understanding the role of melanocortin signaling pathways in diseases and for developing targeted therapies in dermatological and metabolic research.

Reference

[1]. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.