Agomelatine hydrochloride

• CAT Number: I000628
• CAS Number: 1176316-99-6
• Molecular Formula: C15H18ClNO2
• Molecular Weight: 279.76
• Purity: ≥95%
• Synonyms: (Z)-N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetimidic acid hydrochloride
• Target: Neuronal Signaling
• Solubility: DMSO 49 mg/mL; Water <1 mg/mL; Ethanol 49 mg/mL
• Storage: Store at -20C
• IC50: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b)
• IUPAC Name: N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide;hydrochloride
• InChI: InChI=1S/C15H17NO2.ClH/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13;/h3-7,10H,8-9H2,1-2H3,(H,16,17);1H
• InChIKey: ZJVMEXOLMFNQPX-UHFFFAOYSA-N
• SMILES: CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC.Cl

Agomelatine hydrochloride（Cat No.:I000628）is a synthetic antidepressant that acts as a melatonergic and serotonergic agent. It functions as an agonist of melatonin receptors MT1 and MT2, which regulate the sleep-wake cycle, and as an antagonist of the serotonin receptor 5-HT2C, which is involved in mood regulation. By modulating these pathways, agomelatine helps restore circadian rhythm and improve sleep quality while alleviating symptoms of depression. It is primarily used for treating major depressive disorder, offering advantages such as minimal sedative effects and a lower risk of sexual dysfunction compared to other antidepressants.

Reference

[1]. Chenu F, et al. Role of melatonin, serotonin 2B, and serotonin 2C receptors in modulating the firing activity of rat dopamine neurons. J Psychopharmacol. 2013 Nov 4.

[2]. Karakus E, et al. Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage inrats. Hum Exp Toxicol. 2013 Aug;32(8):846-57.