For research use only. Not for therapeutic Use.
AH 6809 (CAT: I003215) is a notable compound functioning as an antagonist for both EP (prostaglandin E) and DP (prostaglandin D) receptors. This compound exhibits a remarkable affinity for various receptor subtypes, including cloned human EP1, EP2, EP3-III, and DP1 receptors. By binding to these receptors, AH 6809 interferes with the activation of signaling pathways triggered by prostaglandins, which play pivotal roles in inflammation, pain, and various physiological processes.
| Catalog Number | I003215 |
| CAS Number | 33458-93-4 |
| Synonyms | 9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid |
| Molecular Formula | C17H14O5 |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Solubility | DMSO: 8 mg/ml |
| Storage | Store at -20°C |
| IC50 | ~3 nM (EC50 for calcium mobilization by PGE2) [1] |
| InChI | InChI=1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20) |
| InChIKey | AQFFXPQJLZFABJ-UHFFFAOYSA-N |
| SMILES | CC(OC1=CC(OC2=CC=C(C(O)=O)C=C2C3=O)=C3C=C1)C |
| Reference | 1:Biochem Pharmacol. 1995 Nov 9;50(10):1731-3. 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist.Woodward DF,Pepperl DJ,Burkey TH,Regan JW, PMID: 7503778 </br><span>Abstract:</span> On studying the interaction of various ligands with the pharmacologically defined, recombinant human EP2 receptor (Regan et al., Mol Pharmacol 46: 213-220, 1994), we discovered that the putative EP1 receptor antagonist 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809) also has affinity for the human EP2 receptor. Moreover, AH 6809 behaved as an EP2 receptor antagonist and inhibited prostaglandin E2 (PGE2)-stimulated increases in cyclic AMP. These findings have significant implications for studies that employ AH 6809 to determine the pharmacological basis of PGE2-induced responses in human cells and tissues. |
