For research use only. Not for therapeutic Use.
AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis[1].
| Catalog Number | I044051 |
| CAS Number | 2975270-19-8 |
| Synonyms | 6-bromo-2-(4-bromophenyl)-[1,2,4]triazolo[1,5-a]pyridine |
| Molecular Formula | C12H7Br2N3 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H7Br2N3/c13-9-3-1-8(2-4-9)12-15-11-6-5-10(14)7-17(11)16-12/h1-7H |
| InChIKey | METAKUVFAGUKGU-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=NN3C=C(C=CC3=N2)Br)Br |
| Reference | [1]. Tian C, et al. Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model. Eur J Med Chem. 2022;231:114122. |
