For research use only. Not for therapeutic Use.
AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM[1].
AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding[1].
AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth[1].
| Catalog Number | I044599 |
| CAS Number | 1256094-31-1 |
| Synonyms | 2-pyridin-2-yl-6-(trifluoromethoxy)-1H-benzimidazole |
| Molecular Formula | C13H8F3N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C13H8F3N3O/c14-13(15,16)20-8-4-5-9-11(7-8)19-12(18-9)10-3-1-2-6-17-10/h1-7H,(H,18,19) |
| InChIKey | JSNWHSDKJSOXET-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)C2=NC3=C(N2)C=C(C=C3)OC(F)(F)F |
| Reference | [1]. Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131. |
