For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM.<br>IC50 value: 24 nM [3]<br>Target: Ack1<br>Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase [1].The Ack1 inhibitor AIM-100 not only inhibited Ack1 activity but also was able to suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer. Notably, AIM-100 suppressed Ack1 mediated ATM expression and mitigated the growth of radioresistant CRPC tumors [2]. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity [3].</p>
| Catalog Number | I005259 |
| CAS Number | 873305-35-2 |
| Synonyms | N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine |
| Molecular Formula | C23H21N3O2 |
| Purity | ≥95% |
| Target | Ack1 |
| Solubility | in DMSO > 10 mM |
| Storage | Store at -20°C |
| IC50 | 24 nM [3] |
| InChI | InChI=1S/C23H21N3O2/c1-3-8-16(9-4-1)19-20-22(24-14-18-12-7-13-27-18)25-15-26-23(20)28-21(19)17-10-5-2-6-11-17/h1-6,8-11,15,18H,7,12-14H2,(H,24,25,26)/t18-/m0/s1 |
| InChIKey | XNFHHOXCDUAYSR-SFHVURJKSA-N |
| SMILES | C12=NC=NC(NC[C@H]3OCCC3)=C1C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O2 |
| Reference | <p style=/line-height:25px/> |
