AIM-100

• CAT Number: I005259
• CAS Number: 873305-35-2
• Molecular Formula: C23H21N3O2
• Molecular Weight: 371.43
• Purity: ≥95%
• Synonyms: N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
• Target: Ack1
• Solubility: in DMSO > 10 mM
• Storage: Store at -20°C
• IC50: 24 nM [3]
• InChI: InChI=1S/C23H21N3O2/c1-3-8-16(9-4-1)19-20-22(24-14-18-12-7-13-27-18)25-15-26-23(20)28-21(19)17-10-5-2-6-11-17/h1-6,8-11,15,18H,7,12-14H2,(H,24,25,26)/t18-/m0/s1
• InChIKey: XNFHHOXCDUAYSR-SFHVURJKSA-N
• SMILES: C1C[C@H](OC1)CNC2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC=CC=C5

AIM-100（Cat No.:I005259）is a novel small molecule inhibitor that targets the NLRP3 inflammasome, a protein complex involved in the body’s inflammatory response. The NLRP3 inflammasome plays a crucial role in various inflammatory diseases, such as rheumatoid arthritis, Alzheimer’s disease, and cardiovascular conditions. By inhibiting this inflammasome, AIM-100 has shown potential in reducing excessive inflammation and may be useful in treating diseases characterized by chronic inflammatory responses. It is currently undergoing clinical research to evaluate its safety, efficacy, and potential as a therapeutic agent for inflammatory and autoimmune disorders.